Src tyrosine kinase, autoinhibited
Src tyrosine kinase in its closed, autoinhibited conformation — the regulatory baseline that activation has to overcome.
Kinases
Protein kinases catalyze the transfer of a phosphate group from ATP onto specific residues of substrate proteins. They are central regulators of nearly every signaling pathway in eukaryotic cells.
2Simulations
1.85 ÅAverage resolution
2Contributors
All Kinases simulations
Filter in browseProtein kinase A, catalytic subunit
PKA catalytic subunit bound to ATP and substrate peptide — the textbook reference structure for protein kinases.