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Src tyrosine kinase in its closed, autoinhibited conformation — the regulatory baseline that activation has to overcome.

PKA catalytic subunit bound to ATP and substrate peptide — the textbook reference structure for protein kinases.

Src tyrosine kinase in its closed, autoinhibited conformation — the regulatory baseline that activation has to overcome.

PKA catalytic subunit bound to ATP and substrate peptide — the textbook reference structure for protein kinases.